An observational study was conducted on the efficacy of Neramexane in a small cohort of Hispanic subjects who were diagnosed with moderate to severe subjective tinnitus. Patients were screened using the inclusion and exclusion criteria as outlined by the study sponsor. The study protocol involved daily intake of Neramexane 50 mg/day (for weigh<90 kg) or 75 mg/day (weight>90 kg) for 29 weeks with primary efficacy assessed through audiogram study and 3 electronic self-reporting questionnaires: Tinnitus Handicap Inventory-12 (TBF/THI-12) Scale, Tinnitus Rating Scale (TRS) and Hospital Anxiety and Depression Scale (HADS).
NIH Funded Articles
- Predictors of Obstructive Sleep Apnea Risk among Blacks with Metabolic Syndrome
- Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites
- Objectively Coding Intervention Fidelity During A Phone-Based Obesity Prevention Study
- Endothelial Cells May Have Tissue-Specific Origins
- Acculturation and Subclinical Atherosclerosis among U.S. South Asians: Findings from the MASALA study
- Wake-up Strokes Are Similar to Known-Onset Morning Strokes in Severity and Outcome
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Rehabilitation Providers’ Perspective on Recovery Following Autologous Chondrocyte Implantation: A Qualitative Study
Autologous Chondrocyte Implantation involves a lengthy recovery process. Rehabilitation providers have an opportunity to positively influence outcomes. To explore and describe the experiences of rehabilitation providers’ experiences during the rehabilitation process following autologous chondrocyte implantation (ACI) and to determine what strategies they employ to improve outcomes, encourage rehabilitation adherence, and establish positive therapist-patient relationships.
Synthetic marijuana compounds are more potent than ∆9-tetrahydrocannabinol (∆9-THC) and are known to produce a wide variety of clinical symptoms including cardiac toxicity, seizures, and death. Erratic driving by a 45 y/o male was witnessed in the fall of 2017 and roadside evaluation of the driver by the responding law enforcement officer concluded that the driver was intoxicated. Comprehensive analysis of the cigarettes by gas chromatography-mass spectrometry detected the synthetic cannabinoid 5-fluoro-ADB (5F-ADB or 5F-MDMB-PINACA). Validated forensic liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were used to detect the 5-fluoro ADB metabolite 7 (26.37 ng/mL) in the driver’s blood sample. No other drugs were detected. This case report is one of the first to conclusively show that designer synthetic cannabinoids, commonly referred to as “K2” and “Spice”, can significantly impair driving at relatively low concentrations.
Oral Carcinoma in Young-Clinico-Pathological Profile and Survival Outcomes in a North Indian Population
To study the prevalence, clinico-pathological profile and survival outcome of oral squamous cell carcinoma in young patients (<40 years).